Blar i forfatter "Haugsten, Ellen Margrethe"

Viser treff 1-2 av 2

    • Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model 

      Krzyscik, Mateusz Adam; Zakrzewska, Malgorzata; Sørensen, Vigdis; Øy, Geir Frode; Bruheim, Skjalg; Haugsten, Ellen Margrethe; Mælandsmo, Gunhild Mari; Wiedlocha, Antoni; Otlewski, Jacek (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-20)
      Worldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer therapy. Therefore, the search for new targeted anti-cancer drugs is still an unmet need. Here, we present novel protein–drug conjugates that inhibit tumor growth in a mouse model of human breast cancer. We developed conjugates based on fibroblast ...

    • Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma 

      Fiorito, Elisa; Szybowska, Patrycja Maria; Haugsten, Ellen Margrethe; Kostas, Michal Janusz; Øy, Geir Frode; Wiedlocha, Antoni; Singh, Sachin Kumar; Nakken, Sigve; Mælandsmo, Gunhild Mari; Fletcher, Jonathan A.; Meza, Leonardo Zepeda; Wesche, Jørgen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-12)
      Background: Rhabdomyosarcoma (RMS) is a paediatric cancer driven either by fusion proteins (e.g., PAX3-FOXO1) or by mutations in key signalling molecules (e.g., RAS or FGFR4). Despite the latter providing opportunities for precision medicine approaches in RMS, there are currently no such treatments implemented in the clinic.<p> <p>Methods: We evaluated biologic properties and targeting strategies ...